The different faces of Janus kinase inhibition
نویسندگان
چکیده
منابع مشابه
The Janus Faces of iNOS
To the Editor: Recently, two groups have reported on the phenotype of transgenic mice with cardiac-specific overexpression of the inducible nitric oxide synthase (iNOS). Although both used the -MHC promoter to target iNOS expression, our model used the tetracyclineregulated system ( MtTA /iNOS ),1 whereas the other used a nonconditional approach.2 Intriguingly, the phenotypes reported varied dr...
متن کاملThe Janus Faces of NO?
To the Editor: The functional effects of myocardial iNOS expression are still a matter of controversy.1 To directly address the role of iNOS on myocardial function, two transgenic animal models with cardiacspecific overexpression of iNOS have been generated.2,3 Mungrue et al describe the generation and analysis of a binary transgenic mouse model for a tetracycline-inducible, cardiac-specific ex...
متن کاملThe Janus faces of iNOS.
To the Editor: Recently, two groups have reported on the phenotype of transgenic mice with cardiac-specific overexpression of the inducible nitric oxide synthase (iNOS). Although both used the -MHC promoter to target iNOS expression, our model used the tetracyclineregulated system ( MtTA /iNOS ),1 whereas the other used a nonconditional approach.2 Intriguingly, the phenotypes reported varied dr...
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Objective(s): The Janus kinase-signal transducers and activators of transcription signaling pathway (JAK/STAT pathway) play an important role in proliferation of breast cancer cells. Previous data showed that inhibition of STAT3 suppresses the growth of breast cancer cells, but the associated mechanisms are not well understood. This study aims to investigate the effect and associated mechanisms...
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JAK2, a member of the Janus kinase (JAK) family of protein tyrosine kinases (PTKs), is an important intracellular mediator of cytokine signaling. Mutations of the JAK2 gene are associated with hematologic cancers, and aberrant JAK activity is also associated with a number of immune diseases, including rheumatoid arthritis. Accordingly, the development of JAK2-specific inhibitors has tremendous ...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2012
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2012.066449